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DFS Week 4 Breakdown: Best Matchups, Top Picks & Winning Strategies | Cashing Points

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Published: September 27, 2025

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In this podcast episode, the analysts break down NFL Week 4 from a DFS lens, discussing injury news, matchup leverage, and value plays across the slate. Key matchups they dive into include Rams–Colts, Eagles–Buccaneers, Bears–Raiders, and more as they spotlight stacking ideas, under-the-radar picks, and lineup strategies.🔍 Topics Covered

Injury & Status Updates

Mike Evans (Bucs) is out with a hamstring injury, making Emeka Egbuka and Sterling Shepard more attractive targets. Bleeding Green Nation+2Reuters+2

Davante Adams (Rams) missed practice again this week with a hamstring issue. His status is uncertain for the Rams–Colts matchup. The Times of India+1

49ers QB Brock Purdy is expected to return this week, restoring more upside to their passing attack. New York Post

Colts WR Alec Pierce is dealing with a concussion and likely out, which increases opportunity for other pass catchers. Stampede Blue

High-Scoring / High-Implied Total Games to Watch

Rams vs. Colts is one of the highest total games on the slate. Taking shots with receivers there has strong upside. Fantasy Points+2FantasyLabs+2

Bears vs. Raiders also looks juicy from a DFS perspective — both defenses have been vulnerable to passing attacks. Fantasy Points

Eagles–Buccaneers is a matchup to monitor given Evans’ absence and possible cornerback matchups in Philly’s secondary. Footballguys+1

Top Plays & Value Ideas

Puka Nacua continues to be a top-tier WR play. He leads in multiple metrics and looks compelling as a pay-up option. FantasyLabs+2CBSSports.com+2

Without Evans, Egbuka gains appeal as a WR option in Tampa’s offense.

Watch for cheaper WRs or rookie dart throws in Colts’ offense now that Pierce might be out. Stampede Blue

On the Bears side, Rome Odunze remains attractive in a pass-friendly game environment. Fantasy Points

Strategy and Lineup Construction

The analysts emphasize correlation stacking (QB + WR/TE), especially in high-scoring games.

Late-swap flexibility is critical this week given several lingering injury questions.

They also discuss ownership leverage — sometimes fading a chalk play opens up more upside elsewhere.

By the end of the show, listeners will have actionable DFS lineups for Week 4, including both safe floor plays and upside rockets that can win tournaments.

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