| Coaches | |
|---|---|
| Position | Name |
| Head Coach | Kyle Shanahan |
| Offensive Coordinator | Klay Kubiak |
| Defensive Coordinator | Robert Saleh |
| Special Teams Coach | Brant Boyer |
| Offense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| QB | 13 | Brock Purdy | 10 | Mac Jones | 4 | Kurtis Rourke(R) | 14 | Tanner Mordecai | ||
| RB | 23 | Christian McCaffrey | 31 | Isaac Guerendo | 29 | Jordan James(R) | 32 | Patrick Taylor | 49 | Corey Kiner(R) |
| LWR | 11 | Brandon Aiyuk | 5 | Demarcus Robinson | 18 | Isaiah Hodgins | 3 | Malik Knowles | 7 | Equanimeous St. Brown |
| SWR | 15 | Jauan Jennings | 19 | Jacob Cowing | 84 | Russell Gage | 86 | Junior Bergen(R) | ||
| RWR | 1 | Ricky Pearsall | 17 | Jordan Watkins(R) | 14 | Isaiah Neyor(R) | 83 | Terique Owens | ||
| TE | 85 | George Kittle | 89 | Luke Farrell | 9 | Brayden Willis | 82 | Ross Dwelley | 88 | Jake Tonges |
| FB | 44 | Kyle Juszczyk | ||||||||
| LT | 71 | Trent Williams | 65 | Andre Dillard | 60 | Sebastian Gutierrez | ||||
| LG | 78 | Ben Bartch | 63 | Nick Zakelj | 69 | Zack Johnson | ||||
| C | 64 | Jake Brendel | 61 | Matt Hennessy | 66 | Drake Nugent | ||||
| RG | 77 | Dominick Puni | 75 | Connor Colby(R) | 55 | Drew Moss(R) | ||||
| RT | 68 | Colton McKivitz | 74 | Spencer Burford | 62 | Austen Pleasants | 67 | Isaac Alarcon | ||
| Defense | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | NO | Player 4 | NO | Player 5 |
| LDE | 97 | Nick Bosa | 94 | Yetur Gross-Matos | 51 | Robert Beal Jr. | 96 | Jonathan Garvin | ||
| RDE | 98 | Mykel Williams(R) | 47 | Bryce Huff | 91 | Sam Okuayinonu | NA | Jaylon Allen | ||
| LDT | 92 | Jordan Elliott | 99 | CJ West(R) | 93 | Kalia Davis | ||||
| RDT | 90 | Kevin Givens | 95 | Alfred Collins(R) | 58 | Evan Anderson | 55 | Sebastian Valdez(R) | ||
| WLB | 53 | Dee Winters | 45 | Nick Martin(R) | 57 | Luke Gifford | 41 | Jalen Graham | 50 | Stone Blanton(R) |
| MLB | 54 | Fred Warner | 48 | Tatum Bethune | 59 | Curtis Robinson | 46 | Chazz Surratt | ||
| LCB | NA | Renardo Green | NA | Eli Apple | 43 | Tre Avery | 49 | Jakob Robinson(R) | ||
| RCB | 2 | Deommodore Lenoir | 28 | Darrell Luter Jr. | 26 | Chase Lucas | 35 | Dallis Flowers | ||
| SS | 24 | Richie Grant | 27 | Ji'Ayir Brown | 38 | Jaylen Mahoney | ||||
| FS | 25 | Jason Pinnock | 6 | Malik Mustapha | 36 | Marques Sigle(R) | ||||
| NB | 20 | Upton Stout(R) | 22 | Tre Brown | 33 | Siran Neal | 40 | Derrick Canteen(R) | ||
| Special Teams | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| POS | NO | Player 1 | NO | Player 2 | NO | Player 3 | ||||
| P | 7 | Thomas Morstead | ||||||||
| K | 4 | Jake Moody | 3 | Greg Joseph | ||||||
| LS | 46 | Jon Weeks | ||||||||
| PR | 19 | Jacob Cowing | 1 | Ricky Pearsall | ||||||
| KR | 32 | Patrick Taylor | 31 | Isaac Guerendo | ||||||
| H | 7 | Thomas Morstead | ||||||||
| KO | 4 | Jake Moody | 3 | Greg Joseph | ||||||
